glycosaminoglycans

glycosaminoglycans
(= formerly mucopolysaccharides)
Polysaccharide side-chains of proteoglycans made up of repeating disaccharide units (more than 100) of amino sugars, at least one of which has a negatively charged side-group (carboxylate or sulphate). Commonest are hyaluronate (D-glucuronic acid- N-acetyl-D-glucosamine: MW up to 10 million), chondroitin sulphate (D-glucuronic acid- N-acetyl-D-galactosamine-4 or -6-sulphate), dermatan sulphate (D-glucuronic acid- or L-iduronic acid- N-acetyl-D-galactosamine), keratan sulphate (D-galactose- N-acetyl-D-glucosamine-sulphate), and heparan sulphate (D-glucuronic acid- or L-iduronic acid- N-acetyl-D-glucosamine). Glycosaminoglycan side chains (with the exception of hyaluronate) are covalently attached to a core protein at about every 12 amino acid residues to produce a proteoglycan; these proteoglycans are then non-covalently attached by link proteins to hyaluronate, forming an enormous hydrated space-filling polymer found in extracellular matrix. The extent of sulphation is variable and the structure allows tremendous diversity.

Dictionary of molecular biology. 2004.

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Look at other dictionaries:

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  • glucosaminoglycans — Glycosaminoglycans (or mucopolysaccharides) in which all of the constituent sugar amines are glucosamines …   Medical dictionary

  • Heparin — Systematic (IUPAC) name see Hep …   Wikipedia

  • Glycosaminoglycan — For other uses of GAGs see Gag (disambiguation) Chondroitin sulfate …   Wikipedia

  • Hyaluronan — Identifiers CAS number 9004 61 9  …   Wikipedia

  • Mucopolysaccharidosis — MPS I redirects here. For zhuyin or bopomofo, a phonetic system for romanizing Chinese, also known as Mandarin Phonetic Symbols I, see Bopomofo. Mucopolysaccharidosis Classification and external resources ICD 10 E76 ICD 9 …   Wikipedia

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  • Chondroitin sulfate — Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin 4 sulfate: R1 = H; R2 = SO3H; R3 = H. Chondroitin 6 sulfate: R1 = SO3H; R2, R3 = H …   Wikipedia

  • Myxedema — Myxoedema Classification and external resources Hyaluronan, an example of a mucopolysaccharide. ICD 10 E …   Wikipedia

  • Glucosamine — IUPAC name …   Wikipedia

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